Noncoding regions are the major component of human genomes and the long noncoding RNA (lncRNA) is a class of pervasive genes located in noncoding regions. lncRNAs play a wide range of regulatory roles in gene transcription, translation, epigenetic modification and protein function by interacting with different types of molecules including DNA, RNA and protein. The diverse interacting partners of lncRNAs pose a challenge to unveil the functional significance of most lncRNAs. Due to the different interacting molecule types and binding modes, the prediction of lncRNA interaction partner is still very difficult. Fortunately, mounting experimental studies reported the function and interaction partners of different lncRNAs during the recent decade. Thus, collecting and integrating these lncRNA interaction data is a primary step to decipher the code of lncRNA interaction.
lncRInter is reliable and high quality lncRNA interaction database containing experimentally validated data. The lncRNA interaction datasets are all extractd from peer-reviewed publications by our curators with strict criteria that there were certain experimental evidence (e.g. RNA pull-down, luciferase reporter assay, in vitro binding assay, etc.) for direct lncRNA interactions.
Publication for more information and for citing this work:
lncRInter: A database of experimentally validated long non-coding RNA interaction
Chun-Jie Liu;Changhan Gao;Zhaowu Ma;Renhuai Cong;Qiong Zhang*;An-yuan Guo*
Journal of Genetics and Genomics 2017;doi:10.1016/j.jgg.2017.01.004
- July, 2015, the first version of lncRInter database was released.