RNA editing is a widespread post-transcriptional mechanism that can make discrete changes to specific nucleotide sequences within a RNA transcripts. RNA editing events can result in missense codon changes in mRNA, modulation of alternative splicing in mRNA, or modification of regulatory RNAs and their binding sites in small noncoding RNA, such as miRNA. Recent studies have developed computational methods to accurately detect more than 2 million A-to-I RNA editing from next-generation sequencing data in different species. However, the vast majority of these RNA sites are in noncoding regions of the genome and have unknown functional relevance. LNCediting provides a comprehensive resource for the functional prediction of RNA editing in long noncoding RNAs (lncRNAs).
Predict the structure of lncRNA influenced by the A→I editing in the lncRNA sequence.
Predict the loss and gain of miRNA:lncRNA binding sites influenced by an A→I editing in the lncRNA sequence.